Funded Intramural Research Projects
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Funded Intramural Research Projects
Hendricks Intramural Pilot and Bridge Program
| PI | Department | Title |
| Tamara Jamaspishvili | Pathology | Studying the prognostic and predictive role of PD-L1 expression on digital pathology images using artificial intelligence in a pan-cancer retrospective patient cohort undergoing immunotherapy |
| Leszek Kotula | Urology | Defining mechanisms of hormone treatment-induced dementia: the role of ABI1 in dendritic spines |
| Hong Lu | Pharmacology | Novel drug/mRNA co-delivery to the liver-lung axis to overcome glucocorticoid resistance and multiorgan dysfunction syndrome in sepsis |
| David Lubin | Radiology | Novel Theranostic Binding Protein based on Human Ubiquitin |
| Carlos Muniz | Neurology | Cardiac safety of antiseizure medications |
| Jushuo Wang | Cell & Developmental Biology | Analyses of off-target effects on cardiac muscle by inhibitors of the UPS and Non-UPS designed to treat multiple myeloma |
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PI |
Department | Title |
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Surgery |
A translational study of a novel nanotrap for sepsis treatment using patient blood samples |
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| Neuroscience & Physiology |
Generation of EYS mutant marmoset embryos |
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| Physical Therapy Education |
Promoting fine hand motor skill learning in chronic stroke survivors using transcranial photobiomodulation |
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| Biochemistry & Molecular Biology |
Directed evolution approach to investigate the structure-based DNA binding mechanism of RNA polymerase I Core Factor |
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| Cell & Developmental Biology |
Assay development for analysis of the motor activity of class I myosins |
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| Biochemistry & Molecular Biology |
Mechanism and Detection of LECT2 amyloidosis |
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| Physical Therapy Education Physical Therapy Education |
The SPROUT Project: Starting pregnancy with robustness for optimal upward trajectories |
| PI | Department | Title |
| Jessica Henty-Ridilla | Cell & Developmental Biology | Dynamic interplay of actin, microtubules & protein aggregates in ALS |
| Xin Jie Chen | Biochemistry & Molecular Biology | Role of mitochondrial proteostatic signaling in neurodegeneration |
| David Pruyne and Jeffrey Amack | Cell & Developmental Biology | Formins and skeletal muscle development in the zebrafish embryo |
| Dimitra Bourboulia | Urology | Mechanism of Tyr phosphorlyation of TIMP2 by SRC kinase |
| Brian Nicholas | Otolaryngology | The Preservation of Hearing Function During Cisplatin Therapy Using a Telodendrimer Nanocarrier in a Mouse Model |
| Eric Olson | Neuroscience and Physiology | Identification of signaling pathways disrupted by fetal alcohol exposure |
Cancer Center Pilot Program
| PI | Department | Title |
| Jason Horton | Orthopedics | Targeted inhibition of EWS:Fli1 for treatment and radiosensitization of Ewing sarcoma |
| Robert Hutchison | Pathology | Modulation of PD-L1 expression in lymphoma cell lines by chemotherapy |
| Bruce Knutson | Biochemistry & Molecular Biology | Enhancing the broad-spectrum application of anti-cancer RNA polymerase I inhibitors in aggressive p53 mutant cancers |
| Leszek Kotula | Urology | Molecular Basis of Lung Metastasis: Tumor Microenvironment |
| Mira Krendel | Cell & Developmental Biology | The role of myosin 1e in breast cancer progression and metastasis |
| Megan Oest | Orthopedics | Mechanisms Regulating Dysfunctional Repair of Post-Radiotherapy Bone Fragility Fractures |
| Guirong Wang | Surgery | Mechanisms of TP53 genetic polymorphisms on RNA splicing processes and gene expression in the pathogenesis of lung cancer |
Carol M. Baldwin Breast Cancer Research Fund of CNY
| PI | Department | Title |
| Brittany Simone | Radiation Oncology | Metabolic reprogramming of host immunity in breast cancer |
| Lisa Lai | Surgery | A novel miRNA-based breast cancer screening approach |