Funded Intramural Research Projects
-
Funded Intramural Research Projects
Hendricks Intramural Pilot and Bridge Program
| PI | Department | Title |
| Dimitra Bourboulia | Urology | Regulation of the Extracellular HSP90 chaperone machinery |
| David Pruyne | Cell & Developmental Biology | FHOD proteins in striated muscle cytoskeletal organization |
| Brian Howell | Neuroscience & Physiology | REELIN’S role in combatting Alzheimer’s |
| Bruce Knutson | Biochemistry & Molecular Biology | Exploring new roles of the human RNA polymerase I associated factors |
| Ryan Palumbo | Biochemistry & Molecular Biology | Developing a platform to characterize Treacher Collins Syndrome mutations using Drosophila melanogaster |
| Justin Ryan | Pharmacology | Development of an ECG-Based Algorithm for Assessing Respiratory Function from Non-Standard ECG Leads |
| Xinru Wang | Microbiology & Immunology | Establish and Characterize Embryo Cell Lines from the Tick, Haemaphysalis longicornis |
| Mark Woodford | Urology | Molecular regulation of the cellular succinylation cycle |
| Sijun Zhu | Neuroscience & Physiology | Investigating mechanisms of polarized secretion of axon guidance molecule Slit from neurons |
| PI | Department | Title |
| Harish Babu | Neurosurgery | Single neuron correlates of emotional stimuli in human prefrontal cortex |
| Andrew Craig | Pediatrics | Laboratory Analyses of Relapse Following Voluntary Abstinence |
| Auyon Ghosh | Medicine | Transcriptomic Predictors and Biomarkers of Sepsis-Induced Cariomyopathy |
| Huaiyu Hu | Neuroscience & Physiology | Generation of a next generation usher syndrome model |
| Yan-Jang Huang | Microbiology & Immunology | Development of an Attenuation Strategy for West Nile Virus by Impairing the Flavivirus Conserved Membrane Fusion Mechanism |
| William Kerr | Microbiology & Immunology | Exploration and Validation of SHIPi Approaches in Models of Alzheimer’s Disease |
| Yi-Ling Kuo | Physical Therapy Education | Using Repetitive Transcranial Magnetic Stimulation to Manage Headaches and Improve Rehabilitation Outcomes in Mild Traumatic Brain Injury: A Longitudinal Study |
| Yamin Li | Pharmacology | Novel cationic lipid nanoparticle-enabled head and neck cancer vaccine |
| David Pruyne | Cell & Developmental Biology | FHOD proteins in striated muscle cytoskeletal organization |
| FRET-based probes for measuring force distribution in living muscle | ||
| Daniel Tso | Neurosurgery | Assessing Vascular Pathology in Diabetic Retinopathy Using Retinal Neurovascular Imaging |
| Cynthia Weickert | Neuroscience & Physiology | Discovering How Inflammation Impairs Neurogenesis in Human Brain |
| Stephan Wilkens | Biochemistry & Molecular Biology | Regulation of the human vacuolar H+-ATPase by TLDc domain proteins |
| PI | Department | Title |
| Tamara Jamaspishvili | Pathology | Studying the prognostic and predictive role of PD-L1 expression on digital pathology images using artificial intelligence in a pan-cancer retrospective patient cohort undergoing immunotherapy |
| Leszek Kotula | Urology | Defining mechanisms of hormone treatment-induced dementia: the role of ABI1 in dendritic spines |
| Hong Lu | Pharmacology | Novel drug/mRNA co-delivery to the liver-lung axis to overcome glucocorticoid resistance and multiorgan dysfunction syndrome in sepsis |
| David Lubin | Radiology | Novel Theranostic Binding Protein based on Human Ubiquitin |
| Carlos Muniz | Neurology | Cardiac safety of antiseizure medications |
| Jushuo Wang | Cell & Developmental Biology | Analyses of off-target effects on cardiac muscle by inhibitors of the UPS and Non-UPS designed to treat multiple myeloma |
|
PI |
Department | Title |
|
Surgery |
A translational study of a novel nanotrap for sepsis treatment using patient blood samples |
|
| Neuroscience & Physiology |
Generation of EYS mutant marmoset embryos |
|
| Physical Therapy Education |
Promoting fine hand motor skill learning in chronic stroke survivors using transcranial photobiomodulation |
|
| Biochemistry & Molecular Biology |
Directed evolution approach to investigate the structure-based DNA binding mechanism of RNA polymerase I Core Factor |
|
| Cell & Developmental Biology |
Assay development for analysis of the motor activity of class I myosins |
|
| Biochemistry & Molecular Biology |
Mechanism and Detection of LECT2 amyloidosis |
|
| Physical Therapy Education Physical Therapy Education |
The SPROUT Project: Starting pregnancy with robustness for optimal upward trajectories |
| PI | Department | Title |
| Jessica Henty-Ridilla | Cell & Developmental Biology | Dynamic interplay of actin, microtubules & protein aggregates in ALS |
| Xin Jie Chen | Biochemistry & Molecular Biology | Role of mitochondrial proteostatic signaling in neurodegeneration |
| David Pruyne and Jeffrey Amack | Cell & Developmental Biology | Formins and skeletal muscle development in the zebrafish embryo |
| Dimitra Bourboulia | Urology | Mechanism of Tyr phosphorlyation of TIMP2 by SRC kinase |
| Brian Nicholas | Otolaryngology | The Preservation of Hearing Function During Cisplatin Therapy Using a Telodendrimer Nanocarrier in a Mouse Model |
| Eric Olson | Neuroscience and Physiology | Identification of signaling pathways disrupted by fetal alcohol exposure |
Cancer Center Pilot Program
| PI | Department | Title |
| Jason Horton | Orthopedics | Targeted inhibition of EWS:Fli1 for treatment and radiosensitization of Ewing sarcoma |
| Robert Hutchison | Pathology | Modulation of PD-L1 expression in lymphoma cell lines by chemotherapy |
| Bruce Knutson | Biochemistry & Molecular Biology | Enhancing the broad-spectrum application of anti-cancer RNA polymerase I inhibitors in aggressive p53 mutant cancers |
| Leszek Kotula | Urology | Molecular Basis of Lung Metastasis: Tumor Microenvironment |
| Mira Krendel | Cell & Developmental Biology | The role of myosin 1e in breast cancer progression and metastasis |
| Megan Oest | Orthopedics | Mechanisms Regulating Dysfunctional Repair of Post-Radiotherapy Bone Fragility Fractures |
| Guirong Wang | Surgery | Mechanisms of TP53 genetic polymorphisms on RNA splicing processes and gene expression in the pathogenesis of lung cancer |
Carol M. Baldwin Breast Cancer Research Fund of CNY
| PI | Department | Title |
| Brittany Simone | Radiation Oncology | Metabolic reprogramming of host immunity in breast cancer |
| Lisa Lai | Surgery | A novel miRNA-based breast cancer screening approach |